Chen Zhihui

I. Doctor Overview

Dr. Chan Chi Wai, CarinaHe/She is a specialist in reproductive medicine in Hong Kong, and alsoGrateful Healthcare(Gratia Medical Centre) Founder, currently providing reproductive medicine and obstetrics/gynecology clinical services at Gratitude Medical, and serving as Honorary Clinical Assistant Professor in the Department of Obstetrics and Gynaecology at the University of Hong Kong’s Faculty of Medicine.

Dr. Chen has dedicated many years to the field of reproductive medicine, combining qualifications as an obstetrician and gynecologist with an academic background in medical genetics, and specializes inInfertilitySystematic evaluation, full-process management of assisted reproductive technologies, and genetic risk counseling for reproduction, with services covering pre-conception guidanceFertility PreservationFull-cycle female reproductive needs up to preimplantation genetic testing.

II. Core Professional Advantages

1. Dual-Dimensional Specialty Qualification Certification

Dr. Chen ZhihuiHolds subspecialty accreditation in reproductive medicine from both the Royal College of Obstetricians and Gynaecologists (UK) and the Hong Kong College of Obstetricians and Gynaecologists, possesses full Fellowship status in obstetrics and gynaecology, has undergone systematic specialist training in obstetrics, gynaecology, and reproductive medicine, and provides comprehensive clinical care across all aspects of women’s reproductive health.

2. Interdisciplinary Background in Reproductive Medicine and Genetics

She holds a Master of Science in Medical Genetics from The Chinese University of Hong Kong, and isHong Kong Reproductive SpecialistFew physicians possess deep expertise in genetics. For families with a history of genetic diseases, known genetic risks, or those requiring preimplantation genetic testing, reproductive assessment and genetic risk analysis can be integrated into fertility treatment to develop more comprehensive diagnostic and therapeutic plans.

3. Bidirectional Empowerment Between Academia and Clinical Practice

As an Honorary Clinical Assistant Professor in the Department of Obstetrics and Gynaecology at the Li Ka Shing Faculty of Medicine, University of Hong Kong, Dr. Chan continuously aligns with cutting-edge clinical guidelines within the academic system, integrating evidence-based medicine into clinical decision-making to avoid overtreatment while ensuring that treatment plans comply with international specialist standards.

4. A Complete Clinical Care Pathway Through Collaboration Among Licensed Institutions

Grateful for healthcare and licensedAssisted Reproductive Technology in Hong KongCenter (HKARCThrough in-depth collaboration, Dr. Chen leads the preliminary assessment, treatment plan development, and ovulation induction management, while HKARC performs IVF procedures such as egg retrieval and embryo culture within the scope of regulatory compliance, establishing a complete service loop that integrates “clinical care + compliant laboratory services.”

5. Full-cycle coverage of reproductive needs

Services include guidance on natural conception,Artificial inseminationIVF, egg freezing, genetic counseling, and multiple other stages. Treatment pathways can be personalized based on the patient’s age, ovarian reserve, prior treatment history, and reproductive goals, rather than uniformly recommending high-intensity treatments.

III. Educational Background and Professional Certifications

Education

• The University of Hong Kong, Faculty of Medicine: Bachelor of Medicine and Bachelor of Surgery (MBBS)

• The Chinese University of Hong Kong: Master of Science in Medical Genetics

Professional Qualifications

• Fellow of the Royal College of Obstetricians and Gynaecologists (MRCOG)

• Fellow of the Royal College of Obstetricians and Gynaecologists (FRCOG)

• Fellow of the Hong Kong Academy of Medicine (Obstetrics and Gynaecology) (FHKAM)

• Fellow of the Hong Kong College of Obstetricians and Gynaecologists (FHKCOG)

• Certificate of the Reproductive Medicine Subspecialty Committee of the Royal College of Obstetricians and Gynaecologists (Cert RCOG, Reprod Med)

• Recognition Certificate in Reproductive Medicine, Hong Kong College of Obstetricians and Gynaecologists (Cert HKCOG, Reprod Med)

Academic Appointments

Honorary Clinical Associate Professor, Department of Obstetrics and Gynaecology, Faculty of Medicine, The University of Hong Kong

The above information is compiled from the official team materials of Gratitude Medical and Hong Kong Assisted Reproduction Center.

IV. Clinical Expertise and Scope of Practice

1. Infertility System Assessment and Assisted Reproductive Treatment Plan

For couples who have been trying to conceive for over one year without achieving natural pregnancy, conduct a comprehensive etiological evaluation of both partners, identify the core factors contributing to infertility, and then develop a stepwise treatment plan.

• Women's Assessment Program: Ovulation function and menstrual cycle analysis, ovarian reserve testing (AMH, antral follicle count), assessment of tubal patency, and imaging evaluation of uterine structure

• Male Assessment ProjectRoutine semen analysis, with further reproductive specialist evaluation if necessary

• Treatment pathway: Provide a stepwise treatment plan based on the underlying cause, including natural conception guidance, ovulation induction with medication, intrauterine insemination (IUI), and in vitro fertilization (IVF), avoiding unnecessary escalation of therapy.

  

2. In Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI)

Covering the entire process of core assisted reproductive technologies, with individualized protocol adjustments throughout:

1. Ovulation Induction PhaseTailor ovarian stimulation protocols based on age, ovarian reserve, and prior treatment response, while monitoring follicular development and hormone levels.

2. Oocyte retrieval procedureUltrasound-guided transvaginal oocyte retrieval, performed in compliance by a partnered licensed center

3. Fertilization and CultureBased on semen quality and prior fertilization history, select either conventional IVF or ICSI for fertilization, followed by embryo culture in the laboratory.

4. Embryo transfer: Schedule fresh or frozen embryo transfer based on embryo quality and endometrial status

5. Embryo cryopreservationSurplus embryos that meet storage standards shall be cryopreserved in accordance with regulatory requirements.

   

Note: ICSI is indicated only for specific medical conditions such as severe male factor infertility or prior fertilization failure, and is not a routine upgrade from IVF; it must be selected strictly according to established indications.

3. Egg Freezing and Fertility Preservation

Provide professional assessment and egg freezing services for women who delay childbearing or need to preserve their fertility due to medical treatments:

• Key evaluation dimensions: age at freezing, ovarian reserve level, expected number of retrieved oocytes, and required number of egg retrieval cycles

• Service Scope: Mature Oocyte Retrieval, Compliant Cryopreservation, and Subsequent Thawing, Fertilization, and Embryo Transfer Coordination

• Objective Note: Egg freezing can preserve fertility potential, but it cannot guarantee 100% success in subsequent pregnancies. Age is the core factor influencing final outcomes, and early assessment and planning are recommended.

  

4. Preimplantation Genetic Testing (PGT) Counseling

Leveraging expertise in medical genetics, we provide comprehensive professional counseling throughout the entire PGT process, clearly defining the applicable scope of the three techniques:

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Important note: PGT is not a universal “embryo quality upgrade” technique; it cannot eliminate all genetic risks, nor does it guarantee implantation or live birth. The decision on whether to undergo testing and which type of test to select must be made based on a comprehensive assessment of genetic risk, the number of embryos available, and treatment goals.

5. Gynecology and Women's Reproductive Health Management

In addition to assisted reproductive technology, the center also offers services such as diagnosis and treatment of common gynecological conditions, preconception health assessments, and routine women's health screenings. Specialized procedures involving breast surgery and minimally invasive surgery are performed by the corresponding specialists within the institution, ensuring professional and high-quality care.

V. Professional Features: The Integrated Value of Reproductive Medicine and Genetics

Dr. Chen Zhihui’s background in medical genetics is of core value in helping patients accurately determine the necessity of testing, avoiding unnecessary medical expenses, and providing compliant genetic reproductive options for high-risk families:

• Ordinary infertile families with no clear genetic riskDo not blindly recommend PGT-A; instead, prioritize optimizing the treatment plan based on core factors such as ovarian function, uterine environment, and embryo quality.

• Families with single-gene genetic disease carriersFirst, complete genetic counseling to clarify the risk of disease in offspring, then assess the feasibility and technical protocols for PGT-M.

• Families with chromosomal structural abnormalitiesIntegrating karyotype analysis results, evaluate the clinical value and limitations of PGT-SR to formulate reproductive decisions.

For families with genetic needs, it is recommended to complete genetic counseling and design a testing plan before initiating IVF, to avoid inadequate preparation after embryo formation.

VI. Practicing Institution: Gratia Medical Centre

1. Institutional Overview

Gratitude Medical Care (GMC), formerly known as the Hong Kong Fertility and Wellness Center established in 2007 by Dr. Chan Chi-hui, is a specialized medical institution focused on women’s health across their entire life cycle. Headquartered in Central, Hong Kong’s core business district, its multidisciplinary team covers fields including reproductive medicine, obstetrics and gynecology, surgery, traditional Chinese medicine, psychological counseling, and nutrition. The institution primarily offers an integrated service model combining “reproductive healthcare + women’s wellness.”

2. Core Service Scope

• Fertility Assessment and Infertility Diagnosis and Treatment

• Intrauterine Insemination (IUI)

• Full-Cycle Clinical Management of In Vitro Fertilization (IVF/ICSI)

• Egg Freezing and Fertility Preservation

• Preimplantation Genetic Testing Counseling

• Routine Gynecological and Obstetric Care and Women's Health Screening

3. Collaboration Model with the Hong Kong Assisted Reproductive Centre (HKARC)

Gratitude for healthcare as the primary entity in clinical diagnosis and treatment,Hong Kong Assisted Reproductive Center (HKARC)As licensed reproductive technology operating institutions, the two entities maintain a collaborative relationship:

• Grateful Medical: Responsible for initial assessment, treatment plan development, ovulation induction monitoring, and pre- and post-operative care follow-up

• HKARC: Responsible for licensed assisted reproductive technology procedures, including egg retrieval, embryo culture, fertilization, embryo cryopreservation, and embryo transfer

Patients must clarify the division of responsibilities at the time of their visit, as all assisted reproductive technology procedures are performed within licensed premises of HKARC.

VII. Compliance and Licensing Requirements (Regulatory Information as of June 2026)

Assisted reproductive services in Hong Kong are strictly regulated under the Human Reproductive Technology Ordinance. All reproductive technology procedures must be conducted at licensed premises, and relevant information can be verified through the official website of the Human Reproductive Technology Authority of Hong Kong.

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Compliance Reminder for Medical Visits

1. Gratitude Medical and HKARC are separate entities; HKARC’s treatment license does not equate to Gratitude Medical holding an IVF treatment license.

2. The clinic address currently listed on Gratitude Medical’s official website (34th Floor, Tower 1, New World Centre) differs from the registered licensed address with AIH. It is recommended to verify the actual location where procedures such as artificial insemination are performed before your visit.

3. When selecting a service, it is essential to verify that the facilities where core procedures such as egg retrieval, embryo culture, and transplantation are performed hold the corresponding licenses, thereby ensuring compliance with medical regulations.

8. Suitable Patient Groups

1. Couples who have been trying to conceive for more than one year without success and wish to undergo a systematic evaluation of infertility causes and develop a stepwise assisted reproductive treatment plan

2. Families who have a clear need for IVF/ICSI treatment and seek individualized protocols and standardized clinical care processes

3. Women who plan to delay childbearing or need to preserve their fertility due to medical treatments, and who wish to evaluate egg freezing.

4. Families requiring combined reproductive and genetic counseling due to risks of monogenic disorders, chromosomal structural abnormalities, and other genetic conditions

5. Patients of advanced age with recurrent implantation failures who seek a professional assessment of PGT applicability

IX. Pre-Visit Decision Recommendations

1. Bring all previous medical records to avoid redundant testsPrepare reports such as AMH, basal hormone levels, antral follicle count, hysterosalpingography, and semen analysis in advance. Patients with a history of IVF should bring their complete ovarian stimulation protocol, egg retrieval records, and embryo culture reports to improve the efficiency of the initial consultation.

2. Clarify the division of clinical responsibilities and identify the responsible partiesConfirm in advance which institutions and physicians are responsible for ovulation induction monitoring, egg retrieval surgery, embryo culture, and transfer procedures, respectively, and clearly define the entities responsible for managing subsequent complications and embryo custody.

3. View success rates rationally and pay attention to statistical definitionsThe publicly disclosed pregnancy rates by institutions are aggregated population-level data and cannot be directly equated with individual outcomes. It is recommended to consult stratified metrics such as clinical pregnancy rates, cumulative live birth rates, and cycle cancellation rates specific to your age group, rather than relying on a single, generalized figure.

4. Clarify the complete fee breakdownIn addition to the basic package, confirm the detailed fee structure for ICSI, blastocyst culture, PGT testing, embryo freezing and annual storage fees, and frozen embryo transfer. Inquire about settlement rules in cases of cycle cancellation or when no viable embryos are available, and request that the clinic provide a written itemized cost list.

5. Avoid blindly adding high-end testing itemsEspecially for PGT-type testing, it is essential to first determine whether the test can alter treatment decisions, rather than treating it as a routine option for "improving success rates." Patients with diminished ovarian reserve and few available embryos should carefully evaluate the cost-benefit ratio of such testing.

10. Reservations and Contact Information

Gratia Medical Centre

• Address: 34th Floor, Tower 1, New World Tower, 16–18 Queen's Road Central, Central, Hong Kong

• Tel: +852 2117 3033

• WhatsApp: +852 9018 8248

• Email: gratia@hk-gmc.com

• Official Website:https://hk-gmc.com

• Business Hours:

  • Monday to Friday: 09:00–14:00, 15:00–18:00

  • Saturday: 09:30–13:30

  • Sundays and public holidays: Closed

Appointment arrangements and booking details are subject to the institution's official real-time responses.