Dr. Brian Acacio, MD, FACOG

Leading U.S. Expert in Reproductive Endocrinology and Infertility | Founder & Medical Director of Acacio Fertility Center

Dr. Brian Acacio, MD, FACOG, is a renownedReproductive EndocrinologyA subspecialist in Reproductive Endocrinology and Infertility (REI), a board-certified obstetrician-gynecologist, and Fellow of the American College of Obstetricians and Gynecologists (FACOG), with decades of experience in reproductive medicine, specializing inReproductive ImmunologyDirection, expertiseRecurrent implantation failure/Recurrent miscarriageHe is one of the leading experts in reproductive medicine in Southern California, specializing in complex cases of infertility.

I. Core Practice Features

• Dual Board Certification: ABOM in Obstetrics and Gynecology, with dual specialty certification in Reproductive Endocrinology and Infertility. This comprehensive credentialing system meets the high standards for reproductive medicine specialists in the United States.

• Advantages in complex reproductive immunology care: One of the earliest specialists in Southern California to focus on recurrent implantation failure and immune-related recurrent miscarriage, receiving a high volume of referrals for refractory infertility from other clinics.

• End-to-end one-stop assisted reproductive services: With our own fertility center, we offer a full suite of fertility treatments, including IVF, ICSI, PGT-A, donor egg and sperm programs, fertility preservation, and minimally invasive reproductive surgeries.

• Balancing academic teaching and clinical practice: Long-standing service as a clinical lecturer and director of clinical training at multiple institutions and hospitals, with a rich portfolio of scholarly output and repeated recognition through peer-selected awards for authoritative physicians.

  

II. Educational Background and Professional Qualifications

• 1988:Bachelor of Science in Biological Sciences, University of California, Irvine (UCI)

• 1993:Doctor of Medicine (M.D.) degree, George Washington University School of Medicine

• 1993–1997:Obstetrics and Gynecology Residency Training at Los Angeles County – USC Medical Center (LAC+USC Medical Center)

• Subspecialty FellowshipLAC+USC Medical Center Women’s and Children’s Hospital, Fellowship in Reproductive Endocrinology and Infertility, specializing in reproductive immunology and assisted reproductive technology

• Professional Certification:Board-certified in Obstetrics and Gynecology by the American Board of Obstetrics and Gynecology (ABOG), Fellow of the American College of Obstetricians and Gynecologists (FACOG), licensed to practice medicine in California; member of the American Society for Reproductive Medicine (ASRM) and the Pacific Coast Obstetrical and Gynecological Society (PCOGS).

  

III. Professional Experience

Dr. Brian Acacio isAcacio Fertility CenterThe founder and Medical Director of the Center, which operates two campuses in Laguna Niguel and Bakersfield, serving Orange County, Kern County, and Southern California at large. He holds privileges for consultations and surgical procedures at multiple Southern California hospitals, including Mission Hospital, Kern Medical Center, and Adventist Health Glendale. In terms of education, he serves as the Chief of Reproductive Endocrinology and Infertility in the Department of Obstetrics and Gynecology at Kern Medical Center, where he has been involved in resident training and clinical consultations at several institutions, including USC and Loma Linda University, accumulating over a decade of teaching experience. He previously served as Chair of the Pacific Coast Ob-Gyn Society (PCOGS) Committee.

IV. Clinical Expertise and Treatment Philosophy

Recurrent Implantation Failure (RIF)

• For patients with recurrent implantation failure, develop targeted intervention protocols based on a multidimensional assessment encompassing reproductive immunology, endometrial receptivity, and coagulation.

Recurrent Pregnancy Loss (RPL)

• Conduct a comprehensive etiological screening for genetic, immunological, endocrine, and coagulation factors, and develop individualized protocols for pregnancy preservation and intervention.

Complex Reproductive Endocrine Disorders

• Design of individualized ovarian stimulation protocols for refractory polycystic ovary syndrome (PCOS) and diminished ovarian reserve (DOR), balancing the risk of ovarian hyperstimulation with the probability of pregnancy.

Full-cycle Assisted Reproductive Technology

• IVF (In Vitro Fertilization), ICSI (Intracytoplasmic Sperm Injection), PGT-A (Preimplantation Genetic Testing for Aneuploidies), egg and embryo cryopreservation for fertility preservation, coordination of donor egg and sperm programs, minimally invasive reproductive surgery, and gestational carrier management.

  

Featured Treatment Philosophy:

We prioritize uncovering the underlying causes of infertility, with particular emphasis on the impact of immune factors on pregnancy. We reject standardized, assembly-line ovulation induction protocols and instead develop customized assisted reproductive solutions for complex cases, aiming for stable live birth outcomes.

V. Academic Achievements, Honors, and Public Influence

Academic Achievements: Published dozens of papers and delivered keynote speeches at peer-reviewed journals and national academic conferences, with a research focus on reproductive immunology, recurrent implantation failure, and optimization of IVF techniques. Industry Honors: Repeatedly selected for the Super Doctors list and Top Reproductive Specialists in Southern California rankings; these honors are based on peer nominations and mutual evaluations and carry high recognition within the U.S. medical community. Public Influence: Invited to attend the 2024 State of the Union Address to advocate for protecting access to IVF reproductive healthcare; frequently interviewed by major media outlets such as NPR to participate in public education on reproductive health.

VI. Professional Certifications and Language Proficiency

Professional Certification

• American Board of Obstetrics and Gynecology (ABOG) Specialty Certification in Obstetrics and Gynecology

• American Board of Obstetrics and Gynecology (ABOG) Subspecialty Certification in Reproductive Endocrinology and Infertility

• Fellow of the American College of Obstetricians and Gynecologists (FACOG)

• Member of the American Society for Reproductive Medicine (ASRM) and Member of the Pacific Coast Obstetrics and Gynecology Society (PCOGS)

Language Proficiency

• English

VII. Target Patient Population

• Patients with difficult infertility who have experienced multiple failed embryo transfers and recurrent miscarriages, and for whom conventional treatment protocols have been ineffective.

• Women trying to conceive with polycystic ovaries or diminished ovarian reserve who require a customized ovulation induction protocol

• Families requiring IVF, ICSI, PGT-A, egg or embryo freezing, and donor egg assistance